Rare Variant Mutations in Pregnancy-Associated or Peripartum Cardiomyopathy

Rare variant mutations in pregnancy-associated or peripartum cardiomyopathy.

BACKGROUND The term peripartum cardiomyopathy (PPCM) describes dilated cardiomyopathy (DCM) without known cause that occurs during the last month of pregnancy to 5 months postpartum. A related term, pregnancy-associated cardiomyopathy (PACM), refers to DCM onset earlier in pregnancy. Multiple studies have focused on inflammatory, immunologic, and environmental causes. An alternative hypothesis ...

Peripartum cardiomyopathy and triplet pregnancy

peripartum cardiomyopathy in a triplet pregnancy

Peripartum cardiomyopathy (PPCM) is a rare form of dilated cardiomyopathy that occurs in previously healthy women in the last month of pregnancy and up to several months after delivery. The incidence of PPCM is low, but its morbidity and mortality rate are high, with a substantial risk of poor outcome of the pregnancy. Patients who have recovered from PPCM run a high risk of reoccurrence in sub...

Is Cardiomyopathy Associated with Peripartum or Anaphylactic Reaction? Which One?

Anaphylaxis is a severe systemic response by allergen mediated type 1 reaction(decreased systemic vascular resistance, hypotension, increased pulmonary vascular resistance, decreased left ventricular preload) initiated by exposure to a specific antigen in a sensitized organism [3]. Rare cases have been reported in the literature about cardiomyopathy in the setting of anaphylaxis treated with ep...

Gestational Weight Gain and Peripartum Cardiomyopathy in a Twin Pregnancy

Preeclamptic twin pregnancy with larger gestational weight gain (GWG) is suggested to have a higher risk of peripartum cardiomyopathy (PPCM). This was true in a 5-year experience at a single center. A primiparous woman with twins and prepregnancy weight of 51.0 kg exhibited hypertension at gestational week (GW) 32(-6/7) and GWG of 18.3 kg (6.0 kg and 2.9 kg during the last four weeks and one we...